TH-Z827 is a mutant-selective inhibitor targeting KRAS(G12D) with an IC50 of 2.4 µM, demonstrating specificity by not binding to KRAS(WT) or KRAS(G12C). Additionally, it disrupts the KRAS(G12D)-CRAF interaction with an IC50 of 42 µM [1].
Molecular Weight:
498.66
CAS Number:
[2847881-81-4]
Formula:
C30H38N6O
Target:
Ras
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