COX-2/15-LOX-IN-4 (compound 5i) is a dual inhibitor with IC50 values of 0.075 µM for COX-2 and 1.97 µM for 15-LOX. It inhibits LPS-induced production of pro-inflammatory cytokines (IL-6, ROS) and exhibits targeted anti-inflammatory effects [1].
Molecular Weight:
405.49
Formula:
C23H20FN3OS
Target:
Lipoxygenase
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