MAT-POS-e194df51-1 is an orally active, non-covalent, non-peptide inhibitor of the SARS-CoV-2 main protease (M pro) with an IC_50 of 37 nM. It exhibits cytotoxicity, showing EC_50 values of 64 nM in A549-ACE2-TMPRSS2 cells and 126 nM in HeLa-ACE2 cells [
Target:
SARS-CoV
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