JBSNF-000028 is an orally active inhibitor of nicotinamide N-methyltransferase (NNMT), with inhibitory concentration (IC50) values of 0.033 µM for human NNMT (hNNMT), 0.19 µM for monkey NNMT (mkNNMT), and 0.21 µM for mouse NNMT (mNNMT). This compound may
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