HIF-1alpha-IN-6 (compound 3s) is a potent inhibitor of HIF-1alpha with IC50 values of 0.6 nM and 53.3 nM in MiaPaCa-2 and MDA-MB-231 cells, respectively, and it suppresses HIF-1alpha expression by reducing HIF-1alpha mRNA levels [1].
Target:
HIF/HIF Prolyl-Hydroxylase
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