GK444 (Compound 15a), a selective HDAC1/2 inhibitor with IC50 values of 100 nM and 92 nM for HDAC1 and HDAC2 respectively, demonstrates an IC50 of 4.1 µM in Caco-2 cell inhibition. Additionally, GK444 attenuates TGF-beta1-induced COL1A1 mRNA expression in p
Target:
HDAC
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