Cyclotraxin B acetate is an antagonist of TrkB receptors, inhibits BDNF-induced TrkB activity (IC50 = 0.30 nM). Allosterically alters TrkB receptor conformation but does not alter BDNF binding. Prevents BDNF-induced cold allodynia in mice. Also shown to
Molecular Weight:
1260.42
CAS Number:
[TP2068L]
Formula:
C50H77N13O19S3
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