Amylin (AMY3) antagonist (IC50 = 0.3 µM). Protects neuronal cells from Abeta(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Abeta plaque number and total area in a mouse Alzheimers disease model.
Molecular Weight:
3009.36
Formula:
C126H202N42O40S2
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