VH-298 is a potent inhibitor of VHL that stabilizes HIF-alpha and elicits a hypoxic response via a different mechanism, that is the blockade of the VHL:HIF-alpha protein-protein interaction downstream of HIF-alpha hydroxylation by PHD enzymes.
Molecular Weight:
523.65
CAS Number:
[2097381-85-4]
Formula:
C27H33N5O4S
Target:
Ligand for E3 Ligase|||HIF
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