Ube2R2 is an E2 enzyme, which is part of the E1, E2, and E3 cascade responsible for ubiquitination of protein substrates. Ube2R2 is phosphorylated by CK2 before it can bind to SCF (Skp1, Cul1, F-box) subunit beta-TrCP. This E2 catalyzes K48 - linked Ub chai