BX-795 is an inhibitor of 3-phosphoinositide-dependent kinase 1 (PDK1), as well as other kinases including TANK-binding kinase 1 (TBK1), Aurora B and IkB kinase epsilon (IKKepsilon). BX-795 prevents TBK1- and IKKepsilon-mediated activation of IRF3 and production of IFN-beta.