MDM2 is an E3 ubiquitin ligase that targets the p53 protein for proteasomal degradation. Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53. Phosphor
Molecular Weight:
IgG
Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Source:
Rabbit
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