COVID-19

Single-Cell Biology of Barrier Tissues

In this talk, Dr. Ordovas-Montañes will discuss recent studies utilizing single-cell genomics to comprehensively map the cell types, subsets, and states that compose human barrier tissues. He will present findings related to health and disease in the nasal and intestinal mucosa and recent work to understand the potential cellular targets of SARS-CoV-2 in these tissues. He will also share challenges and benefits of flow cytometry as an application to further understand single-cell RNA-sequencing based studies.

Dr. José Ordovas-Montañes, PhD is a principal investigator at Boston Children’s Hospital, assistant professor at Harvard Medical School, associate member at the Broad Institute, and principal faculty at Harvard Stem Cell Institute. As a Damon Runyon Postdoctoral Fellow at MIT, the Broad Institute, and the Ragon Institute, he began charting maps of the human gut and airway, and he discovered how human stem cells can be shaped by and remember inflammation. Since 2019, Dr. Ordovas-Montañes’ team at Boston Children's Hospital has been seeking to understand the principles of how inflammation drives memory formation in human barrier tissues.